Sorafenib Impurity 15 CAS CATO-C4X-112415
| CAS No. | CATO-C4X-112415 |
| Molecular Formula | C8H6ClF3N2O |
| Molecular Weight | 238.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sorafenib Impurity 15 (CAS CATO-C4X-112415, C8H6ClF3N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sorafenib Impurity 15 (C8H6ClF3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3N2O |
| Molecular Weight | 238.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Sorafenib Standards
- Sorafenib Impurity 12 (CAS 343247-69-8)
- Sorafenib Impurity 61 (CAS 284462-78-8)
- Sorafenib EP Impurity A (CAS 284462-37-9)
- Sorafenib Impurity 54 (CAS 1153328-25-6)
- Sorafenib Impurity 27 (CAS 757251-59-5)
- Sorafenib Impurity 45 (CAS 46843-47-4)
- Sorafenib Impurity 30 (CAS 1012058-77-3)
- Sorafenib Impurity 59 (CAS 284462-80-2)
Recommended Standards
- Moxifloxacin Impurity N41 (CAS 172602-81-2)
- 916420-92-3 3-Methoxy-5-(trifluoromethyl)benzoyl chloride MFCD09025410 (CAS 916420-92-3)
- 3-Chloro-5-(trifluoromethyl)picolinimidohydrazide (CAS 2379918-35-9)
- 90931-40-1 2-Chloro-N-[5-(trifluoromethyl)pyridin-2-yl]acetamide MFCD11867372 (CAS 90931-40-1)
- Urapidil Impurity 115 (CAS 148547-51-7)
- Fulvestrant Impurity 8 (CAS 252947-01-6)
- Nalmefene Impurity 15 (CAS CATO-C4X-126815)
- 3,4,5-Triphenyl-4,5-dihydroisoxazole (CAS 14659-67-7)
- Acetoacetanilide (CAS 102-01-2)
- 5-{[4-(benzyloxy)phenyl]methylidene}-1,3-diazinane-2,4,6-trione (CAS 242473-63-8)
- 5-Bromo-2,3-difluoro-4-hydroxybenzoic acid (CAS 1892051-93-2)
- methyl 2-azido-3-[4-chloro-2-(difluoromethoxy)phenyl]prop-2-enoate (CAS 2755782-71-7)
- 2-(4-Boc-1-piperazinyl)pyrimidine-5-carbonitrile (CAS 1241898-04-3)
- CBP501 Affinity Peptide trifluoroacetate salt (CAS 1351804-17-5)
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