Chlortalidone EP Impurity A CAS 345930-32-7
| CAS No. | 345930-32-7 |
| Molecular Formula | C14H9ClO6S |
| Molecular Weight | 340.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 340.74 g/mol gives Chlortalidone EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Chlortalidone EP Impurity A (CAS 345930-32-7), a pharmacopoeial impurity reference standard (molecular formula C14H9ClO6S, MW 340.74 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Chlortalidone EP Impurity A (C14H9ClO6S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Chlortalidone EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9ClO6S |
| Molecular Weight | 340.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chlortalidone Standards
- Chlortalidone EP Impurity B (CAS 5270-74-6)
- Chlortalidone Sulfochloro Impurity (CAS 68592-12-1)
- Chlortalidone EP Impurity D (CAS 1369995-36-7)
- Chlortalidone EP Impurity C (CAS 92874-73-2)
- Chlortalidone Impurity 6 (CAS 68592-11-0)
- Chlortalidone EP Impurity I (CAS 2514668-27-8)
- Chlortalidone Impurity 4 (CAS 118-04-7)
- Chlortalidone Impurity 8 (CAS 2224-77-3)
Recommended Standards
- S-((6-Chloro-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)methyl) O,O-dimethyl phosphorodithioate (CAS 35570-72-0)
- (6-Chloro-4-trifluoromethyl-pyridin-2-ylsulfanyl)-acetic acid [1-dimethylamino-meth-(E)-ylidene]-hydrazide (CAS 1858264-43-3)
- o,o-Diethyl ((3-chloro-4-fluorophenyl)carbamoyl)phosphoramidothioate (CAS 680580-25-0)
- 2-((4-Chlorophenyl)thio)-3-(trifluoromethyl)quinoxaline (CAS 321433-72-1)
- Trazodone Impurity 37 HCl (CAS CATO-C4X-177237)
- Pitavastatin Impurity 43 (CAS CATO-C4X-103743)
- Bromhexine Impurity 46 (CAS 3472-84-2)
- 3-(4-Methoxy-3-nitrophenyl)-2,2-dimethylpropan-1-amine (CAS 1485518-57-7)
- Dicloxacillin EP Impurity A (CAS CATO-C4X-16151)
- Ethyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate (CAS 74840-38-3)
- tert-butyl N-[(3R)-2,5-dioxopyrrolidin-3-yl]carbamate (CAS 163929-77-9)
- 3-Ethyl-2-formamidopentanoic acid (CAS 1343591-60-5)
- 9-(2-Bromoethyl)-9H-carbazol-3-amine (CAS 2442597-58-0)
- Myristoyl Pentapeptide -4 acetate (CAS 959610-30-1(free base))
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com