Chlortalidone EP Impurity B CAS 5270-74-6
| CAS No. | 5270-74-6 |
| Molecular Formula | C14H10ClNO5S |
| Molecular Weight | 339.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Chlortalidone EP Impurity B (C14H10ClNO5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 339.75 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Chlortalidone EP Impurity B (CAS 5270-74-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10ClNO5S and a molecular weight of 339.75 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Chlortalidone EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H10ClNO5S |
| Molecular Weight | 339.75 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlortalidone Standards
- Chlortalidone EP Impurity A (CAS 345930-32-7)
- Chlortalidone Sulfochloro Impurity (CAS 68592-12-1)
- Chlortalidone EP Impurity D (CAS 1369995-36-7)
- Chlortalidone EP Impurity C (CAS 92874-73-2)
- Chlortalidone Impurity 6 (CAS 68592-11-0)
- Chlortalidone EP Impurity I (CAS 2514668-27-8)
- Chlortalidone Impurity 4 (CAS 118-04-7)
- Chlortalidone Impurity 8 (CAS 2224-77-3)
Recommended Standards
- Chlorthalidone impurity 19 (CAS CATO-C4X-158519)
- Dotinurad Impurity 38 (CAS CATO-C4X-249438)
- 3-(2-Chlorophenyl)-5-[(E)-2-[(4-fluorophenyl)amino]ethenyl]-1,2-oxazole-4-carbonitrile (CAS 320425-16-9)
- ethyl 2-(1-((4-chlorophenyl)carbamoyl)-3-oxopiperazin-2-yl)acetate (CAS 1007932-18-4)
- Axitinib Impurity N25 (CAS 1266386-30-4)
- MethylPrednisolone Impurity 66 (CAS CATO-C4X-191966)
- Baloxavir Impurity 17 (CAS 2136287-65-3)
- Methyl 6-(benzyl(methyl)amino)-4-methylnicotinate (CAS 1355194-85-2)
- Tert-butyl (3R,5S)-3-hydroxy-5-methylpiperidine-1-carboxylate (CAS 1932597-68-6)
- 2-(4-Hydroxyphenyl)-N-phenylacetamide (CAS 131179-71-0)
- 5-Chloro-2H-pyrazolo[4,3-d]pyrimidine (CAS 1934463-02-1)
- 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-6-methylpyridin-2-amine (CAS 1513818-14-8)
- 6-Bromo-3-[(2-chlorophenyl)methyl]-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 35977-19-6)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com