Regorafenib Impurity 50 CAS CATO-C4X-104750
| CAS No. | CATO-C4X-104750 |
| Molecular Formula | C12H11FN2O2 |
| Molecular Weight | 234.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Regorafenib Impurity 50 (CAS CATO-C4X-104750) is a certified pharmaceutical impurity reference standard with the molecular formula C12H11FN2O2 and a molecular weight of 234.23 g/mol.
Regorafenib Impurity 50 (C12H11FN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11FN2O2 |
| Molecular Weight | 234.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 10 (CAS 348-90-3)
- Regorafenib Impurity 64 (CAS CATO-C4X-104764)
- Regorafenib Impurity 19 (CAS 350602-02-7)
- Regorafenib Impurity 35 (CAS CATO-C4X-104735)
- Regorafenib Impurity 45 (CAS 39893-50-0)
- Regorafenib Impurity 21 (CAS 88330-63-6)
- Regorafenib Impurity 61 (CAS 327-78-6)
- Regorafenib Impurity 39 (CAS CATO-C4X-104739)
Recommended Standards
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- Calcium Dobesilate Impurity 26 (CAS CATO-C4X-205126)
- n-(5-Amino-2-fluorophenyl)-2-methylfuran-3-carboxamide (CAS 926213-00-5)
- 4-Acetaminophen-D3 Sulfate (CAS 1020718-78-8)
- Beclomethasone dipropionate Impurity 40 (CAS CATO-C4X-147440)
- Aprepitant EP Impurity B (CAS 2206606-86-0)
- Upadacitinib Impurity 2 (CAS 1201187-46-3)
- 4-Bromo-7-methoxy-2-phenylquinoline (CAS 1189107-07-0)
- 1-(2,4,5,6,7,7A-hexahydrobenzofuran-3-yl)ethanone (CAS 362056-68-6)
- 2-(tert-Butoxycarbonyl)-2-azaspiro[3.4]octane-5-carboxylic acid (CAS 2306265-72-3)
- 4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-dicarboxylic acid (CAS CATO-CCHM706448)
- 2-(Bromomethyl)-5-(trifluoromethyl)benzo[b]thiophene (CAS 1858256-40-2)
- 1-Hexyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (CAS 593281-04-0)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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