Edoxaban Impurity 93 CAS 349125-08-2
| CAS No. | 349125-08-2 |
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Edoxaban Impurity 93 (CAS 349125-08-2, C9H9ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Edoxaban Impurity 93 (C9H9ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Edoxaban Standards
- Edoxaban Impurity 105 (CAS 2803477-33-8)
- Edoxaban Impurity 34 (CAS 1700085-03-5)
- Edoxaban Impurity 77 (CAS CATO-C4X-106377)
- Edoxaban Impurity 48 (CAS 143150-92-9)
- Edoxaban Impurity 98 (CAS 365997-32-6)
- Edoxaban Impurity 107 (CAS CATO-C4X-1063107)
- Edoxaban Impurity 113 (CAS CATO-C4X-1063113)
- Edoxaban impurity 133 (CAS CATO-C4X-1063133)
Recommended Standards
- Apixaban Impurity 93 (CAS 40345-06-0)
- Indobufen Impurity 24 (CAS 33254-87-4)
- Nintedanib Impurity 63 (CAS 2653-15-8)
- N-(5-Chloro-4-methyl-2-nitrophenyl)acetamide (CAS 7149-78-2)
- Rosuvastatin Impurity 260 (CAS CATO-C4X-1169260)
- Vericiguat Impurity 31 (CAS CATO-C4X-289631)
- Cloperastine Impurity 4 HCl (CAS CATO-C4X-15954)
- N,8-diphenyl-2,4-bis(trifluoromethyl)quinolin-7-amine (CAS 2472802-21-2)
- N-(3,4-dimethoxyphenyl)-1-phenylcyclopentane-1-carboxamide (CAS 923844-17-1)
- 3-Bromo-4-(difluoromethoxy)benzoic acid (CAS 1131615-10-5)
- (3-Phenylthiophen-2-yl)boronic acid (CAS 2225155-73-5)
- 4-Chloro-2-phenylmethoxybenzoic acid (CAS 57479-71-7)
- 3-(Benzo[d]thiazol-2-yl)-2-methylpropanoic acid (CAS 879916-67-3)
- Integrin Binding Peptide trifluoroacetate salt (CAS 278792-07-7)
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