Apixaban Impurity 93 CAS 40345-06-0
| CAS No. | 40345-06-0 |
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apixaban Impurity 93.
Apixaban Impurity 93 (CAS 40345-06-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9ClN2O3 and a molecular weight of 228.63 g/mol.
Structurally, Apixaban Impurity 93 (C9H9ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 228.63 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClN2O3 |
| Molecular Weight | 228.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 91 (CAS 1801881-15-1)
- Apixaban Impurity 167 (CAS CATO-C4X-1088167)
- Apixaban Related Compound 1 (CAS 4792-57-8)
- Apixaban Impurity 112 (CAS 38560-30-4)
- Apixaban Impurity 82 (CAS 2614-10-0)
- Apixaban Impurity 102 (CAS 53427-97-7)
- Apixaban Impurity 49 (CAS CATO-C4X-108849)
- Apixaban Impurity 61 (CAS 62522-25-2)
Recommended Standards
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