Propafenone EP Impurity A CAS 3516-95-8
| CAS No. | 3516-95-8 |
| Molecular Formula | C15H14O2 |
| Molecular Weight | 226.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Propafenone EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Propafenone EP Impurity A (CAS 3516-95-8, C15H14O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Propafenone EP Impurity A (C15H14O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H14O2 |
| Molecular Weight | 226.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Propafenone Standards
- Propafenone Impurity 28 (CAS CATO-C4X-132228)
- Propafenone Impurity 29 (CAS 36941-00-1)
- Propafenone Impurity 31 (CAS CATO-C4X-132231)
- Propafenone Impurity 30 (CAS 17002-31-2)
- Propafenone EP Impurity H(R-isomer) (CAS 27439-12-9)
- Propafenone EP Impurity H (CAS 487-26-3)
- Propafenone RC 6 (CAS 189766-45-8)
- Propafenone Impurity 23 (CAS CATO-C4X-132223)
Recommended Standards
- Terbutaline Impurity 51 (CAS 34068-01-4)
- Ibuprofen Impurity 26 (CAS 67173-18-6)
- Saxagliptin Impurity 8 (CAS 1445592-86-8)
- Temozolomide Impurity 26 (CAS 13114-72-2)
- Ritonavir Impurity 47 (CAS CATO-C4X-175147)
- Sucralose EP Impurity B (CAS 40631-75-2)
- Fruquintinib Impurity 9 (CAS CATO-C4X-30379)
- Ornidazole Impurity 42 (CAS 95881-05-3)
- 5-Bromo-3-methyl-N-(4-pyridinylmethyl)-2-pyridinamine (CAS 1219976-58-5)
- (5-Iodofuran-2-yl)methanamine (CAS 1158048-50-0)
- Methyl 3,4-dibromo-5-(difluoromethoxy)phenylacetate (CAS 1806293-65-1)
- 4,8-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 1698170-51-2)
- 3-Methoxy-3-methylbutanehydrazide (CAS 1700409-29-5)
- [Ser39-OH] Tirzepatide (CAS CATO-C4X-324041)
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