Nicergoline EP Impurity G CAS 57935-65-6
| CAS No. | 57935-65-6 |
| Molecular Formula | C23H24BrN3O2 |
| Molecular Weight | 454.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicergoline EP Impurity G.
CATO supplies Nicergoline EP Impurity G (CAS 57935-65-6), a pharmacopoeial impurity reference standard (molecular formula C23H24BrN3O2, MW 454.36 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Nicergoline EP Impurity G is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 454.36 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicergoline EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H24BrN3O2 |
| Molecular Weight | 454.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Nicergoline Standards
- Nicergoline EP Impurity A (CAS 38536-28-6)
- Nicergoline Impurity 15 (CAS CATO-C4X-208515)
- Nicergoline EP Impurity B (CAS 35264-46-1)
- Nicergoline EP Impurity E (CAS 57935-66-7)
- Nicergoline EP Impurity H (CAS 192504-81-7)
- Nicergoline (CAS 27848-84-6)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Nicergoline EP Impurity F (CAS 58001-19-7)
Recommended Standards
- tert-butyl N-[5-bromo-4-(dimethoxymethyl)pyrimidin-2-yl]-N-tert-butoxycarbonyl-carbamate (CAS 2377372-58-0)
- 4-((2-Oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)methyl)-N-(3-(trifluoromethyl)benzyl)benzamide (CAS 339025-40-0)
- Tert-butyl (2S,3S)-2-(3-bromobenzyl)-3-(2-(dimethylamino)-2-oxoacetamido)pyrrolidine-1-carboxylate (CAS 2407420-58-8)
- Hydroxychloroquine impurity 82 (CAS CATO-C4X-183582)
- Rimegepant Impurity 98 (CAS CATO-C4X-248798)
- Diphenhydramine impurity 14 (CAS CATO-C4X-142414)
- Flunarizine impurity 55 (CAS CATO-C4X-135755)
- 2-(Iodomethyl)-1,1,1,3,3,3-hexafluoropropane (CAS 883499-40-9)
- 1-(4-(3-Methyl-5-vinylpyridin-2-yl)piperazin-1-yl)ethanone (CAS 1355189-57-9)
- 2-(Piperidin-4-yl)acetonitrile (CAS 202002-66-2)
- 4-(Methylsulfanyl)-3-(trifluoromethoxy)phenylboronic acid (CAS 1005206-27-8)
- 2-(Piperidin-4-yloxy)benzo[d]thiazole hydrochloride (CAS 1185319-37-2)
- 3-Fluoro-4-trifluoromethylbenzeneboronic acid pinacol ester, 97% (CAS 445303-67-3)
- Acetyl tetrapeptide-3 (CAS 827306-88-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com