Nicergoline EP Impurity E CAS 57935-66-7
| CAS No. | 57935-66-7 |
| Molecular Formula | C23H24BrN3O3 |
| Molecular Weight | 470.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicergoline EP Impurity E.
CATO supplies Nicergoline EP Impurity E (CAS 57935-66-7), a pharmacopoeial impurity reference standard (molecular formula C23H24BrN3O3, MW 470.36 g/mol) used for the identification and quantification of trace impurities in APIs.
Nicergoline EP Impurity E (C23H24BrN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicergoline EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H24BrN3O3 |
| Molecular Weight | 470.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Nicergoline Standards
- Nicergoline Impurity 15 (CAS CATO-C4X-208515)
- Nicergoline EP Impurity B (CAS 35264-46-1)
- Nicergoline EP Impurity H (CAS 192504-81-7)
- Nicergoline (CAS 27848-84-6)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Nicergoline EP Impurity F (CAS 58001-19-7)
- Nicergoline EP Impurity G (CAS 57935-65-6)
- Nicergoline-13C-d3 (CAS CATO-C4X-208513)
Recommended Standards
- (E)-{[4-(4-chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]methylidene}amino 4-chlorobenzoate (CAS 478041-88-2)
- Beclometasone Impurity 38 (CAS CATO-C4X-147438)
- (E)-2-(4-chlorophenyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole-3-carbaldehyde O-(2-chlorobenzoyl) oxime (CAS 478041-91-7)
- N-Boc-3-(2-Bromo-2-ethoxycarbonylvinyl)-2-phenylindole (CAS 1017968-67-0)
- Olaparib Impurity 58 (CAS CATO-C4X-113558)
- Nerandomilast impurity 19 (CAS CATO-C4X-347319)
- Ceritinib Impurity 31 (CAS CATO-C4X-104831)
- 4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid (CAS 756851-01-1)
- 5-(Aminomethyl)-N,N-dimethylpyrazin-2-amine (CAS 1211590-90-7)
- Enzalutamide Impurity N7 (CAS 143782-23-4)
- 3-Trifluoromethylphenylboronic acid (CAS 1423-26-3)
- Methyl 2-((tert-butyldimethylsilyl)oxy)-2-(dimethoxyphosphoryl)acetate (CAS 78186-95-5)
- 3,3-Dimethylpyrrolidine-2-thione (CAS 127103-83-7)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com