Azathioprine EP Impurity E Sodium Salt CAS 35681-68-6
| CAS No. | 35681-68-6 |
| Molecular Formula | C4H4N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Azathioprine EP Impurity E Sodium Salt (CAS 35681-68-6), a pharmacopoeial impurity reference standard (molecular formula C4H4N3O3Na, MW 165.08 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Azathioprine EP Impurity E Sodium Salt is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 165.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Azathioprine EP Impurity E Sodium Salt under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H4N3O3 Na |
| Molecular Weight | 165.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >80% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 3 |
Related Azathioprine Standards
- Azathioprine Impurity 9 (CAS 1190008-04-8)
- Azathioprine Impurity 12 (CAS 1192-53-6)
- Azathioprine-13C4 (CAS 1346600-71-2)
- Azathioprine Impurity 6 (CAS 154-42-7)
- Azathioprine EP Impurity B (CAS 157930-13-7)
- Azathioprine Impurity 26 (CAS 18753-82-7)
- Azathioprine Impurity 10 (CAS 253453-91-7)
- Azathioprine Impurity 20 (CAS 302840-04-6)
Recommended Standards
- Melphalan Impurity 26 (CAS CATO-C4X-198826)
- Tadalafil Impurity 73 (CAS 326-61-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com