Azathioprine Impurity 12 CAS 1192-53-6
| CAS No. | 1192-53-6 |
| Molecular Formula | C4H4Cl2N2 |
| Molecular Weight | 150.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Azathioprine Impurity 12.
As a process- or degradation-related impurity, Azathioprine Impurity 12 (CAS 1192-53-6, C4H4Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Azathioprine Impurity 12 (C4H4Cl2N2) contains a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 150.99 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Azathioprine Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H4Cl2N2 |
| Molecular Weight | 150.99 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Azathioprine Standards
- Azathioprine Impurity N4 (CAS 5167-18-0)
- Azathioprine Impurity 21 (CAS 30467-02-8)
- Azathioprine EP Impurity B (CAS 157930-13-7)
- Azathioprine EP Impurity B (CAS 50-44-2)
- Azathioprine Impurity 9 (CAS 1190008-04-8)
- Azathioprine EP Impurity D (CAS 6339-54-4)
- Azathioprine EP Impurity A (CAS 4531-54-8)
- Azathioprine EP Impurity C (CAS 4897-25-0)
Recommended Standards
- 4-Chloro-1-chloromethyl-1H-pyrazole (CAS 80199-87-7)
- Rel-((1R,2R)-2-bromocyclopropyl)methanol (CAS 108289-50-5)
- 4,5-Dichloro-2-methyl-1H-imidazole (CAS 15965-33-0)
- (2E)-4-Bromo-2-buten-1-ol (CAS 113661-09-9)
- Eldecalcitol Impurity 35 (CAS 307953-25-9)
- Perphenazine EP Impurity A (CAS 10078-25-8)
- Ganciclovir Impurity 18 (CAS CATO-C4X-102118)
- 2-(Difluoromethyl)-3-iodo-4-nitropyridine-6-carboxamide (CAS 1805195-75-8)
- 3-(4-Hydroxyphenyl)-6-methoxy-2h-chromen-2-one (CAS 951989-73-4)
- 3-Amino-2-cyclohexylpropan-1-ol (CAS 130092-31-8)
- 1,3,5-Trichloro-2-vinylbenzene (CAS 15270-64-1)
- 2-(Trimethylsilyl)benzothiazole (CAS 32137-73-8)
- 4-[(Butylamino)methyl]-2-ethoxyphenol (CAS 1019619-04-5)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com