Dexamethasone Sodium Phosphate Impurity B CAS 360-63-4
| CAS No. | 360-63-4 |
| Molecular Formula | C22H30FO8P |
| Molecular Weight | 472.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dexamethasone Sodium Phosphate Impurity B (CAS 360-63-4) is a certified pharmaceutical impurity reference standard with the molecular formula C22H30FO8P and a molecular weight of 472.44 g/mol.
Dexamethasone Sodium Phosphate Impurity B (C22H30FO8P) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Dexamethasone Sodium Phosphate Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H30FO8P |
| Molecular Weight | 472.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 108 (CAS CATO-C4X-1165108)
- Dexamethasone Impurity 109 (CAS CATO-C4X-1165109)
- Dexamethasone Impurity 117 (CAS CATO-C4X-1165117)
- Dexamethasone Impurity 128 (CAS CATO-C4X-1165128)
- Dexamethasone Sodium Phosphate EP Impurity C (CAS CATO-C4X-116522)
- Dexamethasone Sodium Phosphate EP Impurity D (CAS CATO-C4X-116528)
- Dexamethasone Sodium Phosphate EP Impurity E (CAS CATO-C4X-116529)
- Dexamethasone Sodium Phosphate EP Impurity F (CAS CATO-C4X-116530)
Recommended Standards
- Dexamethasone Phosphate (CAS 312-93-6)
- D-Homo B Derivative of Dexamethasone (CAS CATO-C4X-116552)
- 4-Nitrophenyl 2-acetamido-3-O-acetyl-4-6-O-benzylidene-2-deoxy-α-D-glucopyranoside (CAS 23262-56-8)
- Dexamethasone impurity 63 (CAS 1202001-99-7)
- Melatonin impurity 11 (CAS CATO-C4X-229211)
- Moxifloxacin impurity 175 (CAS 104599-90-8)
- Digoxin EP Impurity B (CAS 4562-36-1)
- 3-Methyl-1-((2,3,4-trimethylphenyl)sulfonyl)-1H-pyrazole (CAS 1003987-69-6)
- 2-ethylbenzofuran-3-carboxylic acid (CAS 52489-34-6)
- 1-(cyclohex-1-en-1-yl)-2-methylpropan-2-ol (CAS 76519-80-7)
- Revefenacin impurity 108 (CAS CATO-C4X-2031108)
- 2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (CAS 1159812-70-0)
- Gadodiamide Impurity 6 (CAS CATO-C4X-31436)
- Antistasin-Related Peptide (CAS 161561-46-2)
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