Dexamethasone Sodium Phosphate EP Impurity F CAS CATO-C4X-116530

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-116530
Molecular FormulaC22H30FO8P
Molecular Weight472.44 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Dexamethasone Sodium Phosphate EP Impurity F CAS CATO-C4X-116530 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dexamethasone Sodium Phosphate EP Impurity F.

As a process- or degradation-related impurity, Dexamethasone Sodium Phosphate EP Impurity F (CAS CATO-C4X-116530, C22H30FO8P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Dexamethasone Sodium Phosphate EP Impurity F (C22H30FO8P) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC22H30FO8P
Molecular Weight472.44 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor)
Purity>90%
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)7.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentF-containing

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