Dexamethasone impurity 63 CAS 1202001-99-7
| CAS No. | 1202001-99-7 |
| Molecular Formula | C22H30FO8P |
| Molecular Weight | 472.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Dexamethasone impurity 63 (C22H30FO8P) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 472.44 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Dexamethasone impurity 63 (CAS 1202001-99-7) is a certified pharmaceutical impurity reference standard with the molecular formula C22H30FO8P and a molecular weight of 472.44 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H30FO8P |
| Molecular Weight | 472.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 108 (CAS CATO-C4X-1165108)
- Dexamethasone Impurity 109 (CAS CATO-C4X-1165109)
- Dexamethasone Impurity 117 (CAS CATO-C4X-1165117)
- Dexamethasone Impurity 128 (CAS CATO-C4X-1165128)
- Dexamethasone Sodium Phosphate EP Impurity C (CAS CATO-C4X-116522)
- Dexamethasone Sodium Phosphate Impurity B (CAS 360-63-4)
- Dexamethasone Sodium Phosphate EP Impurity D (CAS CATO-C4X-116528)
- Dexamethasone Sodium Phosphate EP Impurity E (CAS CATO-C4X-116529)
Recommended Standards
- D-Homo B Derivative of Dexamethasone (CAS CATO-C4X-116552)
- Dexamethasone impurity 64 (CAS CATO-C4X-116564)
- Dexamethasone Phosphate (CAS 312-93-6)
- Dexamethasone impurity 65 (CAS 1202002-01-4)
- Epinephrine /Adrenaline Impurity 103 (CAS CATO-C4X-1849103)
- Acetazolamide EP Impurity C (CAS 32873-56-6)
- Epinastine impurity 59 (CAS CATO-C4X-184059)
- Ethyl 2-(3-((4-fluorophenyl)carbamoyl)pyridin-2-yl)acetate (CAS 338392-11-3)
- tert-Butyl (2-(6-formyl-2-oxo-1,2-dihydropyridin-4-yl)ethyl)carbamate (CAS 1393583-43-1)
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