Upadacitinib Impurity 193 CAS CATO-C4X-2405193
| CAS No. | CATO-C4X-2405193 |
| Molecular Formula | C20H21F6N7O2 |
| Molecular Weight | 505.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Upadacitinib Impurity 193 (CAS CATO-C4X-2405193, C20H21F6N7O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Upadacitinib Impurity 193 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 505.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21F6N7O2 |
| Molecular Weight | 505.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Upadacitinib Standards
- Upadacitinib Impurity 21 (CAS 2715120-86-6)
- Upadacitinib Impurity 213 (CAS 2768445-19-6)
- Upadacitinib Impurity 168 (CAS CATO-C4X-2405168)
- Upadacitinib Impurity 130 (CAS CATO-C4X-2405130)
- Upadacitinib Impurity 131 (CAS CATO-C4X-2405131)
- Upadacitinib Impurity 135 (CAS CATO-C4X-2405135)
- Upadacitinib Impurity 5 (CAS CATO-C4X-24055)
- Upadacitinib Impurity 210 (CAS CATO-C4X-2405210)
Recommended Standards
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- 2-((8-Bromooctyl)oxy)tetrahydro-2H-pyran (CAS 50816-20-1)
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