Efavirenz Impurity 13 CAS 927812-33-7
| CAS No. | 927812-33-7 |
| Molecular Formula | C13H11ClF3NO |
| Molecular Weight | 289.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Efavirenz Impurity 13 (CAS 927812-33-7), a pharmacopoeial impurity reference standard (molecular formula C13H11ClF3NO, MW 289.68 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Efavirenz Impurity 13 (C13H11ClF3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 289.68 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Efavirenz Impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClF3NO |
| Molecular Weight | 289.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Aminoalcohol (CAS 154598-58-0)
- Efavirenz Related Compound A (CAS 209414-27-7)
- Efavirenz USP Related Compound A (CAS 209414-27-7；154598-58-0)
- Efavirenz USP Related Compound C (CAS 391860-73-4)
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
Recommended Standards
- ethyl 2-chloro-3,3,3-trifluoro-2-[(3-methylbutanoyl)amino]propanoate (CAS 329182-55-0)
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- 6-Chloro-9-(4-nitrobenzyl)-9H-purine (CAS 4230-26-6)
- 6-tert-Butoxycarbonylamino-3-chloro-2-fluoro-benzoic acid (CAS 1357943-15-7)
- Relugolix Impurity 24 (CAS CATO-C4X-242924)
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- Brexpiprazole Impurity 49 (CAS 2116542-21-1)
- 1,2-Bis(perfluorophenyl)ethane-1,2-dione (CAS 19555-07-8)
- 2-(O-Tolyl)-thiazole-4-carboxylic acid ethyl ester (CAS 885278-51-3)
- Methyl 3-(4-oxo-7-(trifluoromethyl)quinolin-1(4H)-yl)propanoate (CAS 1279207-56-5)
- (S)-1,4-dibromobutan-2-ol (CAS 64028-90-6)
- 15-(2,3-Dimethylphenyl)-4,5-dimethoxy-10,14,15-triazatetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-2(7),3,5,12(16),13-pentaen-11-one (CAS 860788-94-9)
- 2-Fluoro-N-((5-(thiophene-2-carbonyl)thiophen-2-yl)methyl)benzamide (CAS 1421525-86-1)
- Semaglutide impurity 269 (CAS CATO-C4X-2226269)
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