Furosemide Impurity 16 CAS 3740-18-9
| CAS No. | 3740-18-9 |
| Molecular Formula | C7H3Cl3O4S |
| Molecular Weight | 289.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Furosemide Impurity 16.
CATO supplies Furosemide Impurity 16 (CAS 3740-18-9), a pharmacopoeial impurity reference standard (molecular formula C7H3Cl3O4S, MW 289.52 g/mol) used for the identification and quantification of trace impurities in APIs.
Furosemide Impurity 16 (C7H3Cl3O4S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3Cl3O4S |
| Molecular Weight | 289.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 26 (CAS CATO-C4X-140226)
- Furosemide Impurity 55 (CAS 76852-02-3)
- Furosemide Impurity 50 (CAS CATO-C4X-140250)
- Furosemide Impurity 44 (CAS CATO-C4X-140244)
- Furosemide Impurity 31 (CAS 4818-85-3)
- Furosemide Impurity 45 (CAS CATO-C4X-140245)
- Furosemide Impurity 8 (CAS 41332-59-6)
- Furosemide Impurity 19 (CAS CATO-C4X-140219)
Recommended Standards
- N-(2-Chloro-4-methylphenyl) 4-boronobenzamide (CAS 913835-39-9)
- Boronic acid, b-[3-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]- (CAS 874288-26-3)
- 3,4-Dichloro-5-(chlorosulfonyl)benzoic acid (CAS 151104-67-5)
- 4-Benzylcarbamoyl-2-chlorobenzeneboronic acid (CAS 2096334-06-2)
- Levetiracetam EP Impurity A (CAS 67118-31-4)
- Sildenafil Impurity 284 (CAS CATO-C4X-1128284)
- Linagliptin Impurity 92 D-lactate (CAS 168749-30-2(free base))
- 3-Boc-5-exo-amino-3-aza-bicyclo[4.1.0]heptane (CAS 2166258-47-3)
- 3-((Dimethylamino)methyl)-4-propoxybenzaldehyde hydrochloride (CAS 1185007-44-6)
- 2-allyl-6-fluorocyclohexan-1-one (CAS 128846-31-1)
- Methyl 5-(2-methoxybenzoyl)furan-2-carboxylate (CAS 1399662-48-6)
- 5-Bromo-1-chloro-2-(cyclopentyloxy)-3-fluorobenzene (CAS 1881320-70-2)
- 6-Amino-[1,2,4]triazine-5-carboxylic acid (CAS 412278-71-8)
- Autoinducing Peptide I trifluoroacetate salt (CAS 200010-29-3)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com