Hydrocortisone Impurity 71 CAS 37413-94-8
| CAS No. | 37413-94-8 |
| Molecular Formula | C23H30O4 |
| Molecular Weight | 370.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Hydrocortisone Impurity 71 (CAS 37413-94-8, C23H30O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Hydrocortisone Impurity 71 (C23H30O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H30O4 |
| Molecular Weight | 370.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
Related Hydrocortisone Standards
- Hydrocortisone Impurity N3 (CAS 23460-76-6)
- Hydrocortisone Impurity 65 (CAS CATO-C4X-140165)
- Hydrocortisone-d4 (CAS 73565-87-4)
- Hydrocortisone Impurity 63 (CAS 20380-16-9)
- Hydrocortisone 21-Carboxylic Acid (CAS 57172-48-2)
- Hydrocortisone Impurity 55 (CAS CATO-C4X-140155)
- Hydrocortisone EP Impurity O (CAS 154032-37-8)
- Hydrocortisone Impurity 21 (CAS 68473-77-8)
Recommended Standards
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