Hydrocortisone Impurity 21 CAS 68473-77-8
| CAS No. | 68473-77-8 |
| Molecular Formula | C21H30O6 |
| Molecular Weight | 378.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Hydrocortisone Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Hydrocortisone Impurity 21 (CAS 68473-77-8, C21H30O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Hydrocortisone Impurity 21 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 378.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H30O6 |
| Molecular Weight | 378.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
Related Hydrocortisone Standards
- Hydrocortisone EP Impurity O (CAS 154032-37-8)
- Hydrocortisone EP Impurity D (CAS 53-35-0)
- Hydrocortisone EP Impurity H (CAS CATO-C4X-14018)
- Hydrocortisone EP Impurity I (CAS 103795-84-2)
- Hydrocortisone 21-Carboxylic Acid (CAS 57172-48-2)
- Hydrocortisone Impurity 65 (CAS CATO-C4X-140165)
- Hydrocortisone Impurity 71 (CAS 37413-94-8)
- Hydrocortisone EP Impurity E (CAS 7753-60-8)
Recommended Standards
- Budesonide Impurity 34 (CAS 1171-81-9)
- Avibactam Impurity 142 (CAS CATO-C4X-1348142)
- Captopril Impurity 34 (CAS CATO-C4X-119034)
- Lotilaner Impurity 15 (CAS CATO-C4X-325615)
- Tartaric Acid Impurity N1 (CAS 860708-13-0)
- Alfuzosin EP Impurity C (CAS 98902-34-2)
- Ilaprazole Impurity 216 (CAS CATO-C4X-1130216)
- 5-(2,5-Difluorophenyl)pyrimidin-2-ol (CAS 1111108-68-9)
- tert-Butyl 2-formyl-4-methylpyrrolidine-1-carboxylate (CAS 1615221-99-2)
- N-(1-((3-(trifluoromethyl)phenyl)sulfonyl)piperidin-4-yl)benzamide (CAS 860788-10-9)
- N1,N1,N1,N2,N2,N2-Hexamethylethane-1,2-diaminium chloride (CAS 23252-62-2)
- N-Methyl-N-(2-pyrrolidinylmethyl)-1-butanaminedihydrochloride (CAS 1220027-32-6)
- Capivasertib Impurity 6 (CAS 27646-81-7)
- Hexapeptide-10 (CAS 146439-94-3)
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