Hydrocortisone EP Impurity O CAS 154032-37-8

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.154032-37-8
Molecular FormulaC21H30O6
Molecular Weight378.46 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Hydrocortisone EP Impurity O CAS 154032-37-8 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 378.46 g/mol gives Hydrocortisone EP Impurity O distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Hydrocortisone EP Impurity O (CAS 154032-37-8, C21H30O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a flavonoid core, a hydroxyl group, an ether linkage, Hydrocortisone EP Impurity O is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 378.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Hydrocortisone EP Impurity O meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC21H30O6
Molecular Weight378.46 g/mol
AppearanceOff-white to pale yellow crystalline powder
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2001

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