Eltrombopag impurity 140 CAS CATO-C4X-1198140
| CAS No. | CATO-C4X-1198140 |
| Molecular Formula | C14H11NO5 |
| Molecular Weight | 273.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Eltrombopag impurity 140 (CAS CATO-C4X-1198140, C14H11NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C14H11NO5, Eltrombopag impurity 140 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 273.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11NO5 |
| Molecular Weight | 273.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 109 (CAS CATO-C4X-1198109)
- Eltrombopag Impurity 110 (CAS CATO-C4X-1198110)
- Eltrombopag Impurity 111 (CAS CATO-C4X-1198111)
- Eltrombopag Impurity 112 (CAS CATO-C4X-1198112)
- Eltrombopag Impurity 125 (CAS CATO-C4X-1198125)
- Eltrombopag Impurity 126 (CAS CATO-C4X-1198126)
- Eltrombopag Impurity 20 (CAS 376591-94-5)
- Eltrombopag Impurity 56 (CAS 36324-64-8)
Recommended Standards
- Pomalidomide (CAS 19171-19-8)
- (R)-Pomalidomide (CAS 202271-90-7)
- Pomalidomide Impurity 23 (CAS 191732-76-0)
- Nintedanib Impurity 95 (CAS 16320-52-8)
- Josamycin Impurity 8 (CAS CATO-C4X-30158)
- N-Nitroso Macitentan impurity 52 (CAS CATO-C4X-117552)
- Flumazenil EP Impurity C (CAS 1188-33-6)
- N-(3,5-dimethylphenyl)-2-(pyridin-2-ylthio)acetamide (CAS 329079-45-0)
- methyl 2-chloro-5-nitro-pyridine-4-carboxylate (CAS 777899-57-7)
- ethyl 5-amino-1-methyl-4H-pyrrolo[3,2-c]pyrazole-6-carboxylate (CAS 2459388-98-6)
- Daprodustat Impurity 25 (CAS CATO-C4X-240725)
- 2-Chloro-N-(2,4-dibromophenyl)benzamide (CAS 339252-38-9)
- 1-(6-Methoxy-7-methyl-6H-[1,2,5]oxadiazolo[3,4-e]indol-8-yl)ethan-1-one (CAS 306935-64-8)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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