Loperamide EP Impurity D CAS 37743-41-2
| CAS No. | 37743-41-2 |
| Molecular Formula | C29H34N2O2 |
| Molecular Weight | 442.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Loperamide EP Impurity D (CAS 37743-41-2), a pharmacopoeial impurity reference standard (molecular formula C29H34N2O2, MW 442.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Loperamide EP Impurity D (C29H34N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H34N2O2 |
| Molecular Weight | 442.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 2 |
Related Loperamide Standards
- Loperamide Impurity 16 (CAS CATO-C4X-178816)
- Loperamide EP Impurity H (CAS 61299-42-1)
- Loperamide (CAS 53179-11-6)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide EP Impurity F (CAS 106900-12-3)
Recommended Standards
- Ribociclib D8 (CAS 2167898-24-8)
- 3,4,5-Trifluoro-4'-[(trans,trans)-4'-pentyl[1,1'-bicyclohexyl]-4-yl]-1,1'-biphenyl (CAS 137529-43-2)
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- 1,3-Bis((dicyclopentylphosphino)methyl)benzene (CAS 255874-48-7)
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- Ozenoxacin Impurity 65 (CAS CATO-C4X-279665)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
- 2-(5-Chloropyrazin-2-yl)-2,2-difluoroethan-1-ol (CAS 1818341-52-4)
- 5-(Piperidin-2-yl)-1,3,4-thiadiazol-2-amine oxalate (CAS 1177310-91-6)
- (5-Amino-1H-pyrazol-4-yl)(pyridin-2-yl)methanone (CAS 931114-35-1)
- 1-(4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea (CAS 630124-46-8)
- 4,4-Dimethyl-1-(2-methylphenyl)-1,4-dihydropyrimidine-2-thiol (CAS 1142212-49-4)
- 4-Chloro-N-(3-methylbenzyl)aniline (CAS 356530-45-5)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com