Loperamide Impurity 16 CAS CATO-C4X-178816
| CAS No. | CATO-C4X-178816 |
| Molecular Formula | C28H29ClN2O |
| Molecular Weight | 445.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Loperamide Impurity 16 (CAS CATO-C4X-178816, C28H29ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H29ClN2O, Loperamide Impurity 16 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 445.00 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Loperamide Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H29ClN2O |
| Molecular Weight | 445.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loperamide Standards
- Loperamide EP Impurity D (CAS 37743-41-2)
- Loperamide EP Impurity H (CAS 61299-42-1)
- Loperamide (CAS 53179-11-6)
- Loperamide impurity 12 (CAS CATO-C4X-178812)
- Loperamide EP Impurity G (CAS 109572-89-6)
- Loperamide N-Oxide (CAS 217471-03-9)
- Loperamide EP Impurity G (CAS CATO-C4X-178810)
- Loperamide EP Impurity F (CAS 106900-12-3)
Recommended Standards
- Ethyl 2-[(6-{[(4-chlorophenyl)sulfanyl]methyl}-2-phenylpyrimidin-4-yl)sulfanyl]propanoate (CAS 303147-17-3)
- 7-Bromo-4,6-dichloro-8-fluoro-1,2-dihydroquinolin-2-yl trifluoromethanesulfonate (CAS 2857930-14-2)
- Cetirizine Impurity 17 (CAS CATO-C4X-158217)
- 1,2-Bis(5-bromo-2-chlorophenyl)disulfane (CAS 792952-65-9)
- Quetiapine EP Impurity T (CAS 5747-46-6)
- Pemafibrate Impurity 45 (CAS CATO-C4X-290345)
- Ilaprazole Impurity 99 (CAS CATO-C4X-113099)
- [1-(2,2-Difluoroethyl)azetidin-3-yl]methanol (CAS 1491346-76-9)
- 2-(6-(1-Ethyl-1H-pyrazol-3-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 1171776-92-3)
- 4-Cyclopropoxy-5-methylpyridin-3-amine (CAS 1243390-95-5)
- 2-[(E)-[(2E)-3-[4-(Dimethylamino)phenyl]prop-2-en-1-ylidene]amino]thiophene-3-carbonitrile (CAS 866018-15-7)
- Fasitibant (CAS 869939-83-3)
- 4-chloro-3-methylbenzoyl chloride (CAS 21900-24-3)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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