Fluorometholone Impurity 5 CAS 378-36-9
| CAS No. | 378-36-9 |
| Molecular Formula | C22H31FO4 |
| Molecular Weight | 378.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Fluorometholone Impurity 5 (C22H31FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Fluorometholone Impurity 5 (CAS 378-36-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H31FO4 and a molecular weight of 378.48 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fluorometholone Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H31FO4 |
| Molecular Weight | 378.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluorometholone Standards
- Fluorometholone Acetate 6,9(11)-diene Impurity (CAS 95955-20-7)
- Fluorometholone D Homo Derivative (CAS CATO-C4X-19339)
- Fluorometholone (CAS 426-13-1)
- Fluorometholone Impurity 2 (CAS 130145-14-1)
- Fluorometholone Impurity N12 (CAS 382-52-5)
- Fluorometholone Impurity 8 (CAS CATO-C4X-19338)
- Fluorometholone Epoxy Analog (CAS 83873-17-0)
- Fluorometholone Impurity B (CAS 83873-16-9)
Recommended Standards
- Desoximetasone Impurity 6 (CAS 432-54-2)
- Cebranopadol(GRT6005) (CAS 863513-91-1)
- 4,6-Bis((4-fluorophenyl)thio)-2-(methylthio)pyrimidine (CAS 860650-70-0)
- Baxdrostat Impurity 14 (CAS 3084665-74-4)
- Doxapram Impurity 7 (CAS 3471-97-4)
- Sitafloxacin impurity 72 (CAS CATO-C4X-115572)
- Dapoxetine Impurity 5 (CAS 1329834-62-9)
- morphine hydrochloride (CAS 52-26-6)
- 6-Hydrazinyl-2-methylimidazo[1,2-b]pyridazine (CAS 14780-57-5)
- N4-Methylpyrimidine-4,5,6-triamine (CAS 83366-44-3)
- 1-(3,4-Dichlorophenyl)-3,3,3-trifluoropropan-1-one (CAS 1097824-59-3)
- 3-(2-methylpropyl)cyclopentan-1-one (CAS 53002-97-4)
- 2-(2-(Hydroxymethyl)pyrrolidin-1-yl)nicotinonitrile (CAS 1249597-28-1)
- (D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 444073-04-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com