Fluorometholone Impurity 8 CAS CATO-C4X-19338
| CAS No. | CATO-C4X-19338 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Fluorometholone Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Fluorometholone Impurity 8 (CAS CATO-C4X-19338), a pharmacopoeial impurity reference standard (molecular formula C22H29FO5, MW 392.46 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Fluorometholone Impurity 8 (C22H29FO5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Fluorometholone Standards
- Fluorometholone Impurity N12 (CAS 382-52-5)
- Fluorometholone Epoxy Analog (CAS 83873-17-0)
- Fluorometholone Impurity 2 (CAS 130145-14-1)
- Fluorometholone Acetate 6,9(11)-diene Impurity (CAS 95955-20-7)
- Fluorometholone Impurity 5 (CAS 378-36-9)
- Fluorometholone D Homo Derivative (CAS CATO-C4X-19339)
- Fluorometholone (CAS 426-13-1)
- Fluorometholone Acetate (CAS 3801-06-7)
Recommended Standards
- Fluticasone Impurity 56 (CAS CATO-C4X-165056)
- Betamethasone (CAS 378-44-9)
- Betamethasone impurity 98 (CAS CATO-C4X-143798)
- Paramethasone (CAS 53-33-8)
- Ambroxol Impurity 18 (CAS 40525-78-8)
- Rocuronium Impurity 13 (CAS CATO-C4X-124213)
- Crisaborole Impurity 66 (CAS 2247957-30-6)
- Flunarizine (CAS 52468-60-7)
- 5,10-diethyltetradecane-7,8-dione (CAS 1047670-79-0)
- 3-(2-Chlorophenyl)-5-methyl-N-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl)isoxazole-4-carboxamide (CAS 349613-51-0)
- (1R,2S)-Methyl 2-aminocyclohex-3-enecarboxylate (CAS 193673-50-6)
- Halcinonide Impurity 1 (CAS CATO-C4X-27951)
- Phenyl valerate (CAS 20115-23-5)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com