Betamethasone CAS 378-44-9
| CAS No. | 378-44-9 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Betamethasone (CAS 378-44-9), a certified reference material (molecular formula C22H29FO5, MW 392.46 g/mol) for analytical method development and quality control.
Structurally, Betamethasone (C22H29FO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 392.46 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Betamethasone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Impurity 22 (CAS 2990-65-0)
- Betamethasone EP Impurity H (CAS 185613-71-2)
- Betamethasone Impurity 117 (CAS CATO-C4X-1437117)
- Betamethasone Impurity 145 (CAS CATO-C4X-1437145)
- Betamethasone Impurity 34(Mixture of Diastereomers) (CAS 1249-19-0)
- Betamethasone impurity 71 (CAS 37926-76-4)
- Betamethasone EP Impurity I (CAS 185613-69-8)
- Betamethasone impurity 97 (CAS 1150311-95-7)
Recommended Standards
- Fluorometholone Impurity 8 (CAS CATO-C4X-19338)
- Paramethasone (CAS 53-33-8)
- Fluticasone Impurity 56 (CAS CATO-C4X-165056)
- (Des-Tyr1)-Leu-Enkephalin (CAS 60254-83-3)
- 2-Fluoro-4-morpholinoaniline Dihydrochloride (CAS 2006276-93-1)
- Ethyl 2-(3-bromo-4-hydroxy-5-methoxyphenyl)acetate (CAS 1258845-38-3)
- N-(3,4-Dimethylphenyl)-N-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzyl)methanesulfonamide (CAS 409356-56-5)
- Clobetasol Propionate EP Impurity A (CAS 5534-13-4)
- 7-(Hydroxyamino)quinoline-5,8-dione (CAS 94129-60-9)
- 1-(3,4-Dichlorophenyl)-3-((4-ethylphenyl)amino)propan-1-one (CAS 423731-06-0)
- (S)-3-Amino-3-(2-(trifluoromethoxy)phenyl)propanoic acid (CAS 1228561-33-8)
- 2-Methylimidazo[1,5-a]pyrimidine-4-carboxylic acid (CAS 1231758-34-1)
- 2-(3-Chloro-5-fluorophenyl)propan-2-amine hydrochloride (CAS 172402-74-3)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com