Fluorometholone Impurity N12 CAS 382-52-5
| CAS No. | 382-52-5 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Fluorometholone Impurity N12 (CAS 382-52-5, C22H29FO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H29FO5, Fluorometholone Impurity N12 contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 392.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluorometholone Standards
- Fluorometholone Impurity 8 (CAS CATO-C4X-19338)
- Fluorometholone Epoxy Analog (CAS 83873-17-0)
- Fluorometholone Impurity 2 (CAS 130145-14-1)
- Fluorometholone Acetate 6,9(11)-diene Impurity (CAS 95955-20-7)
- Fluorometholone Impurity 5 (CAS 378-36-9)
- Fluorometholone D Homo Derivative (CAS CATO-C4X-19339)
- Fluorometholone (CAS 426-13-1)
- Fluorometholone Acetate (CAS 3801-06-7)
Recommended Standards
- Dexamethasone-4¸6α¸21¸21-[d4] (CAS 2483831-63-4)
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- Betamethasone Impurity 22 (CAS 2990-65-0)
- Dexamethasone (CAS 50-02-2)
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- 5-Methoxy-2-(1H-pyrrol-1-yl)aniline (CAS 59194-26-2)
- (R)-2-amino-2-(6-chloropyridin-3-yl)ethan-1-ol hydrochloride (CAS 2089671-27-0)
- 2-Chloro-5-(trifluoromethyl)pyridine-4-carboxylic Acid (CAS 505084-58-2)
- Sodium N-Myristoylsarcosinate (CAS 30364-51-3)
- Benzyl (S)-4-bromo-2-((tert-butoxycarbonyl)amino)butanoate (CAS 95656-97-6)
- Semaglutide Impurity 115 (CAS CATO-C4X-2226115)
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