Dexamethasone Hemisuccinate CAS 3800-86-0
| CAS No. | 3800-86-0 |
| Molecular Formula | C26H33FO8 |
| Molecular Weight | 492.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dexamethasone Hemisuccinate.
CATO supplies Dexamethasone Hemisuccinate (CAS 3800-86-0), a certified reference material (molecular formula C26H33FO8, MW 492.53 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Dexamethasone Hemisuccinate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 492.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H33FO8 |
| Molecular Weight | 492.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 114 (CAS CATO-C4X-1165114)
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- Dexamethasone impurity 123 (CAS CATO-C4X-1165123)
- Dexamethasone Impurity 127 (CAS CATO-C4X-1165127)
- Dexamethasone 21-Iodide (CAS 2029-18-7)
- Dexamethasone Impurity 16 (CAS 55541-30-5)
- Dexamethasone Impurity 84 (CAS CATO-C4X-116584)
- Dexamethasone Impurity 87 (CAS CATO-C4X-116587)
Recommended Standards
- Betamethasone Succinate (CAS 27297-42-3)
- 6-(4-Methoxyphenyl)-2-((2-tosylethyl)thio)-4-(trifluoromethyl)nicotinonitrile (CAS 625376-41-2)
- Triamcinolone Acetonide Impurity 37 (CAS 72559-83-2)
- 5-(4-(3-(4-Acetylpiperazine-1-carbonyl)phenyl)quinazolin-6-yl)-2-methoxynicotinonitrile (CAS 1431540-99-6)
- 4-(5-(3,4-Dimethoxyphenyl)-1H-1,2,4-triazol-3-yl)aniline (CAS 1279218-26-6)
- 1-(2-Bromo-5-fluorobenzyl)-1H-imidazole (CAS 1333851-81-2)
- 2,7-Diaminopyrene-4,5,9,10-tetraone (CAS 2459874-51-0)
- N-nitroso-elagolix (CAS CATO-C4X-206892)
- (R)-2-(methylamino)-2-(m-tolyl)ethan-1-ol (CAS 1336237-29-6)
- Biphenyl-<SUP>13</SUP>C<SUB>12</SUB> (CAS 104130-36-1)
- 2-(pyridin-4-yl)quinazolin-4-ol (CAS 6484-23-7)
- 6,7-dibromo-4-hydroxy-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazin-1-one (CAS 219783-00-3)
- Ethyl 2-(5-bromo-3-cyano-2-nitrophenyl)acetate (CAS 1804403-64-2)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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