Betamethasone Succinate CAS 27297-42-3
| CAS No. | 27297-42-3 |
| Molecular Formula | C26H33FO8 |
| Molecular Weight | 492.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Betamethasone Succinate (CAS 27297-42-3) is a high-purity analytical reference standard with the molecular formula C26H33FO8 and a molecular weight of 492.53 g/mol.
The molecular framework of Betamethasone Succinate (C26H33FO8) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H33FO8 |
| Molecular Weight | 492.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Valerate EP Impurity H (CAS 52619-18-8)
- Betamethasone Dipropionate EP Impurity D (CAS 5514-81-8)
- Betamethasone impurity 59 (CAS CATO-C4X-143759)
- Betamethasone Impurity 43 (CAS 4735-65-3)
- Betamethasone impurity 52 (CAS 97168-90-6)
- Betamethasone impurity 67 (CAS 13796-49-1)
- Betamethasone Impurity 76 (CAS 5534-01-0)
- Betamethasone Impurity 144 (CAS CATO-C4X-1437144)
Recommended Standards
- 6-(4-Methoxyphenyl)-2-((2-tosylethyl)thio)-4-(trifluoromethyl)nicotinonitrile (CAS 625376-41-2)
- Dexamethasone Hemisuccinate (CAS 3800-86-0)
- 5-(4-(3-(4-Acetylpiperazine-1-carbonyl)phenyl)quinazolin-6-yl)-2-methoxynicotinonitrile (CAS 1431540-99-6)
- Dexamethasone Impurity 114 (CAS CATO-C4X-1165114)
- (S)-3-(4-Hydroxy-1-oxoisoindolin-2-yl)-3-methylpiperidine-2,6-dione (CAS 1323408-31-6)
- Granisetron-d3 (CAS 1224925-76-1)
- 5-(6-Chloropyridazin-3-yl)-3-(thiophen-2-ylmethyl)-1,2,4-thiadiazole (CAS 930002-18-9)
- N-((S)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidin-3-yl)-N-ethylacetamide (CAS 1401668-47-0)
- 5-Amino-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carboxylic acid (CAS 1019009-03-0)
- Amlodipine Impurity 48 (CAS CATO-C4X-109548)
- 3-Hydroxyglutaric Acid (CAS 638-18-6)
- 2-(Thiazol-2-yl)ethan-1-amine hydrochloride (CAS 1072084-99-1)
- Bifendate Impurity A (CAS 118159-47-0)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com