Gefitinib Impurity 47 CAS 3863-11-4
| CAS No. | 3863-11-4 |
| Molecular Formula | C6H5F2N |
| Molecular Weight | 129.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Gefitinib Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Gefitinib Impurity 47 (CAS 3863-11-4, C6H5F2N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Gefitinib Impurity 47 (C6H5F2N) contains a nitrile group, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H5F2N |
| Molecular Weight | 129.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Gefitinib Standards
Recommended Standards
- 695-53-4 ALU9NPM703 Dimethadione Dimethadione [USAN:INN] 2,4-Oxazolidinedione, 5,5-dimethyl- 4-27-00-03237 (Beilstein Handbook Reference) AC 1198 AI3-18201 BAX 1400Z BRN 0113541 Dimetadiona [INN-Spanish] Dimetadione [DCIT] Dimethadion Dimethadionum [INN-Latin] Dimethyloxazolidinedione Dimethyl-oxazolidine-2,4-dione 5,5-Dimethyl-2,4-oxazolidinedione DMO 5,5-Dwumetylooksazolidyno-2,4-dion [Polish] EINECS 211-781-4 Eupractone NSC-30152 Propazone NSC 30152 5,5-Dwumetylooksazolidyno-2,4-dion Dimetadiona Dimetadione Dimethadionum 5,5-Dimethyl-2,4-oxazolidindion [IUPAC] UNII-ALU9NPM703 5,5-Dimethyl-2,4-oxazolidindion (CAS 695-53-4)
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