Pazopanib Impurity 20 CAS 3934-20-1

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.3934-20-1
Molecular FormulaC4H2Cl2N2
Molecular Weight148.98 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Pazopanib Impurity 20 CAS 3934-20-1 chemical structure

Description

Pazopanib Impurity 20 (C4H2Cl2N2) contains a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Pazopanib Impurity 20 (CAS 3934-20-1) is a certified pharmaceutical impurity reference standard with the molecular formula C4H2Cl2N2 and a molecular weight of 148.98 g/mol.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC4H2Cl2N2
Molecular Weight148.98 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1958
Halogen ContentCl-containing
Nitrogen Atoms2

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