Resmetirom Impurity 1 CAS 141-30-0
| CAS No. | 141-30-0 |
| Molecular Formula | C4H2Cl2N2 |
| Molecular Weight | 148.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Resmetirom Impurity 1 (CAS 141-30-0, C4H2Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C4H2Cl2N2, Resmetirom Impurity 1 contains a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 148.98 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Resmetirom Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H2Cl2N2 |
| Molecular Weight | 148.98 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Resmetirom Standards
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
- Resmetirom Impurity 3 (CAS 6629-04-5)
- Resmetirom impurity 133 (CAS 1314924-95-2)
- Resmetirom impurity 135 (CAS 3096249-74-7)
- Resmetirom impurity 64 (CAS 2375196-15-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Resmetirom impurity 134 (CAS 28165-63-1)
- Resmetirom Impurity 4 (CAS 107228-51-3)
Recommended Standards
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- Palbociclib Impurity 205 (CAS 2252258-81-2)
- Ilaprazole Impurity 75 (CAS 102625-98-9)
- Finasteride Impurity 31 (CAS 1667725-37-2)
- 2-(2-Bromophenyl)-5-((2,6-dichlorobenzyl)thio)-1,3,4-oxadiazole (CAS 444157-02-2)
- 1-(5-(2-Chlorophenyl)furan-2-yl)ethan-1-one (CAS 675596-28-8)
- 2-Hydroxy-6-trifluoromethylpyridine (CAS 34486-06-1)
- 4-(Ethoxymethyl)phenol (CAS 57726-26-8)
- 4-(3-Nitrophenoxy)piperidine hydrochloride (CAS 125043-83-6)
- (1R,4R,5R)-1-(furan-2-yl)bicyclo[2.1.1]Hexane-5-carboxylic acid (CAS 2187426-36-2)
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