Crisaborole Impurity 3 CAS 394-47-8
| CAS No. | 394-47-8 |
| Molecular Formula | C7H4FN |
| Molecular Weight | 121.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crisaborole Impurity 3.
CATO supplies Crisaborole Impurity 3 (CAS 394-47-8), a pharmacopoeial impurity reference standard (molecular formula C7H4FN, MW 121.11 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Crisaborole Impurity 3 (C7H4FN) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H4FN |
| Molecular Weight | 121.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 4 (CAS 403-54-3)
- Crisaborole Impurity 46 (CAS 1194-02-1)
- Crisaborole Impurity 63 (CAS 7070-85-1)
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 18 (CAS 2737-20-4)
Recommended Standards
- 34069-57-3 4-amino-2-fluorobutanoic acid 4-azanyl-2-fluoranyl-butanoic acid A822061 (CAS 34069-57-3)
- 5-Ethynyl-2-fluoropyridine (CAS 853909-08-7)
- 4-Fluorophenyl isocyanide (CAS 24075-34-1)
- Vericiguat Impurity 5 (CAS CATO-C4X-28965)
- Belumosudil Impurity 22 (CAS CATO-C4X-298822)
- Iguratimod Impurity 41 (CAS CATO-C4X-182641)
- Esmolol Impurity 52 (CAS CATO-C4X-189152)
- 2-Amino-4-{2-[(4-chlorophenyl)methoxy]phenyl}-6-(hydroxymethyl)-8-oxo-4H,8H-pyrano[3,2-b]pyran-3-carbonitrile (CAS 674805-43-7)
- Benzyl 7-oxo-2-oxa-5-azabicyclo[2.2.2]Octane-5-carboxylate (CAS 2306275-52-3)
- 8A-isopropyldihydro-1H-thiazolo[3,2-a][1,3,5]triazine-2,4(3H,8aH)-dione (CAS 13146-74-2)
- 2-(4-Propylphenyl)ethane-1-thiol (CAS 1267318-95-5)
- 4-(4-Bromophenoxy)benzoic acid (CAS 21120-68-3)
- 2-((4-Butyl-5-((4-chlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-butylphenyl)acetamide (CAS 720667-82-3)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com