Crisaborole Impurity 48 CAS 22532-61-2
| CAS No. | 22532-61-2 |
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 48 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 48 (CAS 22532-61-2) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5BrO2 and a molecular weight of 201.02 g/mol.
Structurally, Crisaborole Impurity 48 (C7H5BrO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 201.02 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
Recommended Standards
- 4-Bromobenzoic Acid (CAS 586-76-5)
- 2-Bromobenzoic Acid (CAS 88-65-3)
- CyclohexylphosphonicdichlorideDISCONTINUED (CAS 1005-22-7)
- N-(2-Bromophenyl)nitrosamide (CAS 876497-67-5)
- Enalapril Impurity 36 (CAS CATO-C4X-133436)
- Bisoprolol Impurity 85 (CAS CATO-C4X-124785)
- Xanomeline impurity 48 (CAS CATO-C4X-330148)
- Cinitapride impurity 6 (CAS CATO-C4X-29086)
- Isopentenyl Tosylate (CAS 781-03-3)
- 1-Cyclopropylcyclobutan-1-amine hydrochloride (CAS 2094149-86-5)
- (1R,2S,3S,5S,6R)-2-Amino-3-Fluorobicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid (CAS 234085-19-9)
- 2-Bromo-N,4-dimethyl-6-nitroaniline (CAS 1805598-11-1)
- ethyl 3-(propan-2-yl)pyrrolidine-3-carboxylate (CAS 1692722-15-8)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com