Crisaborole Impurity 45 CAS 2973-80-0
| CAS No. | 2973-80-0 |
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Crisaborole Impurity 45 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 201.02 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Crisaborole Impurity 45 (CAS 2973-80-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5BrO2 and a molecular weight of 201.02 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole Impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
Recommended Standards
- 4-Bromobenzoic Acid (CAS 586-76-5)
- N-(2-Bromophenyl)nitrosamide (CAS 876497-67-5)
- 2-Bromobenzoic Acid (CAS 88-65-3)
- 3-Bromobenzoic acid (CAS 585-76-2)
- Sumatriptan impurity 2 (CAS CATO-C4X-17572)
- Mirogabalin Imputity 101 (CAS CATO-C4X-2924101)
- Fluoxetine Impurity 15 (CAS CATO-C4X-135215)
- (S)-2-(3-Pyrrolidinyl)-2-propanol Hydrochloride (CAS 1273577-45-9)
- 2881-63-2 3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester Ethyl (4-chlorobenzoyl)acetate Ethyl 3-(4-chlorophenyl)-3-oxopropanoate NSC 406743 (CAS 2881-63-2)
- (6-(tertButoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)boronic acid (CAS 2408429-82-1)
- 2-((3,4-Dimethylphenyl)sulfonyl)acetonitrile (CAS 1008108-48-2)
- 1-(1-(3-Chlorophenyl)ethyl)piperidin-3-amine hydrochloride (CAS 1203266-43-6)
- Solriamfetol Impurity 28 (CAS CATO-C4X-256328)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com