Crisaborole Impurity 1 CAS 20035-32-9
| CAS No. | 20035-32-9 |
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Crisaborole Impurity 1 (CAS 20035-32-9), a pharmacopoeial impurity reference standard (molecular formula C7H5BrO2, MW 201.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C7H5BrO2, Crisaborole Impurity 1 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 201.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Crisaborole Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BrO2 |
| Molecular Weight | 201.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 18 (CAS 2737-20-4)
- Crisaborole Impurity 41 (CAS 2737-19-1)
- Crisaborole Impurity 42 (CAS 1260761-47-4)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- Crisaborole Impurity 43 (CAS 58380-11-3)
Recommended Standards
- N-(2-Bromophenyl)nitrosamide (CAS 876497-67-5)
- 3-Bromobenzoic acid (CAS 585-76-2)
- 25194-52-9 6-Bromo-2-carbamoylpyridine 6-Bromopicolinamide 6-bromopyridine-2-carboxamide (CAS 25194-52-9)
- 6-Bromonicotinamide (CAS 889676-37-3)
- Parecoxib Impurity 37 (CAS CATO-C4X-159137)
- CAS CATO-C3D-262723 (CAS CATO-C3D-262723)
- Almotriptan Impurity 14 (CAS CATO-C4X-153814)
- N-{pyrrolo[1,2-a]quinolin-6-yl}furan-2-carboxamide (CAS 865659-17-2)
- (2,5-Dimethylphenyl)(3-hydroxypiperidin-1-yl)methanone (CAS 1090469-04-7)
- Empagliflozin Impurity 113 (CAS 2452301-16-3)
- 1-(Cyclopentylmethyl)piperidin-4-amine (CAS 64306-78-1)
- 3-(2-(3-Amino-1h-pyrazol-1-yl)ethyl)oxazolidin-2-one (CAS 1341373-68-9)
- 2-(5-(2-Nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-1-(10H-phenothiazin-10-yl)ethanone (CAS 78807-66-6)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
Why CATO?
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