Crisaborole Impurity 4 CAS 403-54-3
| CAS No. | 403-54-3 |
| Molecular Formula | C7H4FN |
| Molecular Weight | 121.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Crisaborole Impurity 4 (CAS 403-54-3, C7H4FN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H4FN, Crisaborole Impurity 4 contains a nitrile group, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 121.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4FN |
| Molecular Weight | 121.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 3 (CAS 394-47-8)
- Crisaborole Impurity 46 (CAS 1194-02-1)
- Crisaborole Impurity 63 (CAS 7070-85-1)
- Crisaborole Impurity 1 (CAS 20035-32-9)
- Crisaborole Impurity 2 (CAS 196081-71-7)
- Crisaborole Impurity 45 (CAS 2973-80-0)
- Crisaborole Impurity 48 (CAS 22532-61-2)
- Crisaborole Impurity 18 (CAS 2737-20-4)
Recommended Standards
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- Methylmalonic Acid-d3 (CAS 42522-59-8)
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