Amlodipine EP Impurity F Maleate CAS 400024-11-5
| CAS No. | 400024-11-5 |
| Molecular Formula | C19H23ClN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amlodipine EP Impurity F Maleate.
Amlodipine EP Impurity F Maleate (CAS 400024-11-5) is a certified pharmaceutical impurity reference standard with the molecular formula C19H23ClN2O5C4H4O4 and a molecular weight of 510.92 g/mol.
Amlodipine EP Impurity F Maleate (C19H23ClN2O5C4H4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H23ClN2O5 C4H4O4 |
| Molecular Weight | 510.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity N32 (CAS 103094-30-0)
- (R)-Amlodipine (CAS 103129-81-3)
- Amlodipine (S)-Isomer (CAS 103129-82-4)
- Amlodipine Impurity N5 (CAS 107812-86-2)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- Amlodipine Besylate (CAS 111470-99-6)
- Amlodipine Impurity N4 (CAS 113994-36-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- Mifepristone Impurity 14 (CAS 84371-69-7)
- Levetiracetam EP Impurity B (CAS 358629-47-7)
- Lasmiditan Impurity 7 (CAS CATO-C4X-24787)
- 2-Ethylpentanoic Acid Ethyl Ester (CAS 43164-26-7)
- 1-Benzyl-4-[(5-benzyloxy-6-methoxy-1-indanone)-2-ylidenyl]methylpiperidine 120013-75-4 2,3-Dihydro-6-methoxy-5-(phenylmethoxy)-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one (CAS 120013-75-4)
- Polymyxin Impurity 25 (CAS CATO-C4X-225525)
- 4-Nitro-1-phenyl-1H-pyrazol-3-amine (CAS 701917-04-6)
- Methyl 3-amino-3-(thiazol-4-yl)propanoate (CAS 1600118-86-2)
- 2-(4-Methyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)acetic acid (CAS 1275729-79-7)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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