Afatinib Impurity 21 CAS 402855-03-2
| CAS No. | 402855-03-2 |
| Molecular Formula | C18H16ClFN4O2 |
| Molecular Weight | 374.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Afatinib Impurity 21 (CAS 402855-03-2) is a certified pharmaceutical impurity reference standard with the molecular formula C18H16ClFN4O2 and a molecular weight of 374.80 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Afatinib Impurity 21 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 374.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Afatinib Impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H16ClFN4O2 |
| Molecular Weight | 374.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 2 (CAS 314771-76-1)
- Afatinib Impurity 58 (CAS CATO-C4X-100658)
- Afatinib Impurity 62 (CAS CATO-C4X-100662)
- Afatinib Impurity 55 (CAS CATO-C4X-100655)
- Afatinib impurity 42 (CAS CATO-C4X-100642)
- Afatinib Impurity 73 (CAS CATO-C4X-100673)
- Afatinib Impurity 82 (CAS CATO-C4X-100682)
- Afatinib Impurity 69 (CAS CATO-C4X-100669)
Recommended Standards
- tert-Butyl (3-chloro-5-cyano-6-fluoro-9H-pyrido[2,3-b]indol-8-yl)(methyl)carbamate (CAS 2245358-51-2)
- N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethyl)-4-methylbenzamide (CAS 1043106-60-0)
- N-(4-chlorophenyl)-3-(2-nitrophenoxy)thiophene-2-carboxamide (CAS 252027-03-5)
- 1-(2-Chloro-4-fluorophenoxy)-3-(2-methoxybenzenesulfonyl)propan-2-ol (CAS 478079-88-8)
- Linagliptin impurity 143 (CAS 2517759-32-7)
- Miglitol Impurity 13 (CAS CATO-C4X-169713)
- Ensifentrine impurity 40 (CAS CATO-C4X-335340)
- N-(4-(Prop-2-yn-1-yl)phenyl)acetamide (CAS 115784-56-0)
- tert-Butyl ((2S,3S)-1-fluoro-3-methylpentan-2-yl)carbamate (CAS 2380804-53-3)
- 5-Phenyl-2-(pyridin-3-yl)oxazole (CAS 106590-21-0)
- 1-(Bromomethyl)-1-(2-ethoxyethyl)cyclopropane (CAS 1479556-02-9)
- 2-Propenoic acid, 2-methyl-, methyl ester, polymer with (1-methylethenyl)benzene and 2-propenenitrile (CAS 25747-75-5)
- 4-CHloro-benzoic acid benzyl ester (CAS 67483-73-2)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com