Afatinib Impurity 73 CAS CATO-C4X-100673
| CAS No. | CATO-C4X-100673 |
| Molecular Formula | C22H14N4O3 |
| Molecular Weight | 382.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Afatinib Impurity 73 (CAS CATO-C4X-100673) is a certified pharmaceutical impurity reference standard with the molecular formula C22H14N4O3 and a molecular weight of 382.37 g/mol.
The molecular framework of Afatinib Impurity 73 (C22H14N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afatinib Impurity 73 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H14N4O3 |
| Molecular Weight | 382.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib impurity 42 (CAS CATO-C4X-100642)
- Afatinib Impurity 55 (CAS CATO-C4X-100655)
- Afatinib Impurity 62 (CAS CATO-C4X-100662)
- Afatinib Impurity 90 (CAS CATO-C4X-100690)
- Afatinib Impurity 2 (CAS 314771-76-1)
- Afatinib Impurity 21 (CAS 402855-03-2)
- Afatinib Impurity 58 (CAS CATO-C4X-100658)
- Afatinib Impurity 60 (CAS CATO-C4X-100660)
Recommended Standards
- N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-2-phenyl-4-quinolinecarboxamide (CAS 851095-32-4)
- Cefpirome Impurity 11 (CAS CATO-C4X-120711)
- Methyl 5-(furan-2-carbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate (CAS 94985-29-2)
- Losartan Impurity 37 (CAS CATO-C4X-168337)
- Acetylcysteine Impurity 17 (CAS CATO-C4X-153217)
- Maxacalcitol Impurity 1 (CAS 169218-34-2)
- Cholic Acid Impurity 69 (CAS 105660-11-5)
- N-(1-Ethylpyrrolidin-2-ylidene)-4-methylbenzenesulfonamide (CAS 126826-49-1)
- 4-bromo-1-(2-ethoxyethoxy)-2-nitrobenzene (CAS 856364-94-8)
- Pirbuterol (CAS 38677-81-5)
- N-(2,5-Dimethoxyphenyl)-2-(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetamide (CAS 1142206-63-0)
- tert-Butyl ((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-1-oxo-3-(1-tosyl-1H-imidazol-4-yl)propan-2-yl)carbamate (CAS 35899-49-1)
- (2R,3S,4R,5R,6R)-5-acetamido-2-(acetoxymethyl)-6-(benzyloxy)tetrahydro-2H-pyran-3,4-diyl diacetate (CAS 13343-66-3)
- C-Peptide (human) (CAS 33017-11-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com