Apixaban Impurity 167 CAS CATO-C4X-1088167
| CAS No. | CATO-C4X-1088167 |
| Molecular Formula | C11H14N2O3 |
| Molecular Weight | 222.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Apixaban Impurity 167 (CAS CATO-C4X-1088167, C11H14N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H14N2O3, Apixaban Impurity 167 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 222.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H14N2O3 |
| Molecular Weight | 222.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 91 (CAS 1801881-15-1)
- Apixaban Impurity 112 (CAS 38560-30-4)
- Apixaban Impurity 102 (CAS 53427-97-7)
- Apixaban Impurity 93 (CAS 40345-06-0)
- Apixaban Impurity 61 (CAS 62522-25-2)
- Apixaban Related Compound 1 (CAS 4792-57-8)
- Apixaban Impurity 82 (CAS 2614-10-0)
- Apixaban Impurity 49 (CAS CATO-C4X-108849)
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- Tocopherol Impurity 31 (CAS CATO-C4X-119531)
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