Apixaban Impurity 112 CAS 38560-30-4
| CAS No. | 38560-30-4 |
| Molecular Formula | C11H12N2O3 |
| Molecular Weight | 220.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Apixaban Impurity 112 (CAS 38560-30-4) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12N2O3 and a molecular weight of 220.22 g/mol.
The molecular framework of Apixaban Impurity 112 (C11H12N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 112 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12N2O3 |
| Molecular Weight | 220.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 167 (CAS CATO-C4X-1088167)
- Apixaban Impurity 91 (CAS 1801881-15-1)
- Apixaban Impurity 102 (CAS 53427-97-7)
- Apixaban Impurity 61 (CAS 62522-25-2)
- Apixaban Impurity 93 (CAS 40345-06-0)
- Apixaban Related Compound 1 (CAS 4792-57-8)
- Apixaban Impurity 82 (CAS 2614-10-0)
- Apixaban Impurity 49 (CAS CATO-C4X-108849)
Recommended Standards
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- 2-((5-(Ethoxycarbonyl)-4-methyl-6-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetic acid (CAS 309268-24-4)
- Azintamide Impurity 2 (CAS 69827-43-6)
- (5-bromo-7-methyl-1-benzofuran-2-yl)methanamine (CAS 1343809-80-2)
- 2,4,6-Tribromobenzene-1,3,5-tricarboxylic acid (CAS 86216-68-4)
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