Rosuvastatin Impurity 169 CAS 404958-69-6
| CAS No. | 404958-69-6 |
| Molecular Formula | C10H19ClO4 |
| Molecular Weight | 238.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 238.71 g/mol gives Rosuvastatin Impurity 169 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Rosuvastatin Impurity 169 (CAS 404958-69-6, C10H19ClO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rosuvastatin Impurity 169 (C10H19ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 238.71 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rosuvastatin Impurity 169 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H19ClO4 |
| Molecular Weight | 238.71 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 111 (CAS 404958-68-5)
- Rosuvastatin Impurity 137 (CAS 325471-28-1)
- Rosuvastatin Impurity 187 (CAS 154026-93-4)
- Rosuvastatin Impurity 59 (CAS 404958-08-3)
- Rosuvastatin Impurity 140 (CAS 154026-92-3)
- Rosuvastatin Impurity 107 (CAS 122549-26-2)
- Rosuvastatin Impurity 266 (CAS 775571-58-9)
- Rosuvastatin Impurity 87 (CAS CATO-C4X-116987)
Recommended Standards
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- 3-Methoxypropylisothiocyanate (CAS 28115-86-8)
- 2,7-Dicyclopropylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid (CAS 1225826-07-2)
- 2-(2-Bromo-5-fluorophenyl)acetaldehyde (CAS 905710-81-8)
- 4-(5,5-Dimethyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-3-hydroxyfuran-2(5H)-one (CAS 50413-16-6)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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