Rosuvastatin Impurity 187 CAS 154026-93-4
| CAS No. | 154026-93-4 |
| Molecular Formula | C10H19ClO4 |
| Molecular Weight | 238.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Rosuvastatin Impurity 187 (CAS 154026-93-4, C10H19ClO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Rosuvastatin Impurity 187 (C10H19ClO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H19ClO4 |
| Molecular Weight | 238.71 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 111 (CAS 404958-68-5)
- Rosuvastatin Impurity 137 (CAS 325471-28-1)
- Rosuvastatin Impurity 169 (CAS 404958-69-6)
- Rosuvastatin Impurity 59 (CAS 404958-08-3)
- Rosuvastatin Impurity 140 (CAS 154026-92-3)
- Rosuvastatin Impurity 107 (CAS 122549-26-2)
- Rosuvastatin Impurity 266 (CAS 775571-58-9)
- Rosuvastatin Impurity 87 (CAS CATO-C4X-116987)
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