Fulvestrant EP Impurity A CAS 407577-53-1
| CAS No. | 407577-53-1 |
| Molecular Formula | C32H47F5O3S |
| Molecular Weight | 606.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Fulvestrant EP Impurity A (CAS 407577-53-1) is a certified pharmaceutical impurity reference standard with the molecular formula C32H47F5O3S and a molecular weight of 606.77 g/mol.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Fulvestrant EP Impurity A is typically off-white to pale yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 606.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Fulvestrant EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H47F5O3S |
| Molecular Weight | 606.77 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fulvestrant Standards
- Fulvestrant (CAS 129453-61-8)
- Fulvestrant S Enantiomer (CAS 1316849-17-8)
- Fulvestrant R Enantiomer (CAS 1807900-80-6)
- Fulvestrant impurity 32 (CAS CATO-C4X-191732)
- Fulvestrant impurity 36 (CAS CATO-C4X-191736)
- Fulvestrant EP Impurity E (CAS 2170200-14-1)
- Fulvestrant impurity 53 (CAS CATO-C4X-191753)
- Fulvestrant-d3 (CAS CATO-C4X-19177)
Recommended Standards
- 5-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-3-[1-(2,4-dichlorophenyl)-3-methyl-5-oxo-1,2,4-triazolidin-3-yl]-3aH,4H,5H,6H,6aH-pyrrolo[3,4-d][1,2]oxazole-4,6-dione (CAS 317822-54-1)
- Biotin-PEG5-NH-Boc (CAS 189209-28-7)
- Ceftolozane Impurity 22 (CAS CATO-C4X-240622)
- 156856-31-4 Fusapyrone 2H-Pyran-2-one, 3-(4-deoxy-beta-xylo-hexopyranosyl)-4-hydroxy-6-(2-hydroxy-7-(hydroxymethyl)-1,1,5,9,11-pentamethyl-3,5,8-heptadecatrienyl)- 3-(4-Deoxy-beta-xylohexapyranosyl)-4-hydroxy-6-(2-hydroxy-7-hydroxymethyl-1,1,5,9,11-pentamethyl-3,5,8-heptadecatrienyl)-2H-pyran-2-one 3-(4-Deoxy-beta-xylo-hexopyranosyl)-4-hydroxy-6-(2-hydroxy-7-(hydroxymethyl)-1,1,5,9,11-pentamethyl-3,5,8-heptadecatrienyl)-2H-pyran-2-one (CAS 156856-31-4)
- Febuxostat Impurity 43 (CAS 161798-03-4)
- Mometasone Furoate EP Impurity D (CAS 83881-09-8)
- Dalbavancin Impurity 59 (CAS CATO-C4X-160259)
- 4-(Cyanomethyl)-6-(difluoromethyl)-3-hydroxypicolinonitrile (CAS 1805359-62-9)
- N-[(1E)-{[(2-bromophenyl)methoxy]imino}methyl]-4-methoxy-2-phenoxypyridine-3-carboxamide (CAS 478262-48-5)
- 2-Methyl-4-((trimethylsilyl)oxy)quinoline (CAS 162283-20-7)
- 4-(8-Methoxyisoquinolin-5-yl)aniline (CAS 919362-95-1)
- Ethyl 2-{[6-chloro-2-(4-chlorophenyl)-1H-1,3-benzimidazol-1-yl]oxy}propanoate (CAS 338978-88-4)
- (2R,3S,4R)-2-(((tert-Butyldiphenylsilyl)oxy)methyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate (CAS 151797-32-9)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
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