Mometasone Furoate EP Impurity D CAS 83881-09-8
| CAS No. | 83881-09-8 |
| Molecular Formula | C27H29ClO6 |
| Molecular Weight | 484.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Mometasone Furoate EP Impurity D (CAS 83881-09-8, C27H29ClO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution, Mometasone Furoate EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 484.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H29ClO6 |
| Molecular Weight | 484.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
Related Mometasone Standards
- Mometasone Impurity 41 (CAS CATO-C4X-170441)
- Mometasone Furoate EP Impurity C (CAS 1305334-31-9)
- Mometasone Furoate EP Impurity N (CAS 352315-75-4)
- Mometasone Impurity 49 (CAS CATO-C4X-170449)
- Mometasone Impurity 34 (CAS CATO-C4X-170434)
- Mometasone Furoate EP Impurity A (CAS 83880-65-3)
- Mometasone Furoate EP Impurity P (CAS CATO-C4X-170416)
- Mometasone Furoate EP Impurity H (CAS 148596-90-1)
Recommended Standards
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