Tacrolimus EP Impurity B CAS CATO-C4X-130045
| CAS No. | CATO-C4X-130045 |
| Molecular Formula | C43H69NO12 |
| Molecular Weight | 792.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tacrolimus EP Impurity B is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tacrolimus EP Impurity B (CAS CATO-C4X-130045, C43H69NO12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C43H69NO12, Tacrolimus EP Impurity B contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 792.01 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C43H69NO12 |
| Molecular Weight | 792.01 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus impurity 44 (CAS 135635-46-0)
- Tacrolimus Impurity 53 (CAS CATO-C4X-130053)
- Tacrolimus EP Impurity A (CAS 104987-12-4)
- Tacrolimus impurity 71 (CAS CATO-C4X-130071)
- Tacrolimus 31 DMT (CAS 135635-47-1)
- Tacrolimus 15-DMT (CAS 151039-41-7)
- Tacrolimus 31-DMT (CAS 127984-76-3)
- Tacrolimus EP Impurity C (CAS CATO-C4X-130025)
Recommended Standards
- Triethyl 5,5',5''-((nitrilotris(methylene))tris(1H-benzo[d]imidazole-2,1-diyl))tripentanoate (CAS 956299-56-2)
- Band 3 Protein (824-829) (human) H-Tyr-Val-Lys-Arg-Val-Lys-OH (CAS 158475-15-1)
- Ascomycin (CAS 11011-38-4)
- DPP48-DCV-Br (CAS 2059936-87-5)
- Isavuconazole Impurity 46 (CAS CATO-C4X-123646)
- Nafamostat Impurity 48 Methanesulfonate (CAS CATO-C4X-133248)
- Rapamycin Impurity 11 (CAS 159351-88-9)
- 1-(5-Nitro-1H-pyrazol-3-yl)ethan-1-one (CAS 39846-83-8)
- 5-chloro-1H-indole-6-carboxylic acid (CAS 1260858-55-6)
- 2-Thioxo-3-(p-tolyl)-2,3-dihydropyrimidin-4(1H)-one (CAS 104369-37-1)
- 5-bromo-4-methyl-indan-1-one (CAS 903557-48-2)
- 2-Amino-1-(2,4-dimethylpiperazin-1-yl)ethanone (CAS 1353976-52-9)
- Albendazole-2-aminosulfonehydrochloride (CAS CATO-CCAD301388)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
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