Neostigmine EP Impurity A methyl sulfate CAS 4312-54-3
| CAS No. | 4312-54-3 |
| Molecular Formula | C9H14NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Neostigmine EP Impurity A methyl sulfate (CAS 4312-54-3, C9H14NOCH3O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Neostigmine EP Impurity A methyl sulfate (C9H14NOCH3O4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Neostigmine EP Impurity A methyl sulfate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H14NO CH3O4S |
| Molecular Weight | 263.31 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Neostigmine Standards
- Neostigmine Bromide (CAS 114-80-7)
- Neostigmine bromide Impurity 14 (CAS 14318-66-2)
- Neostigmine Impurity 24 (CAS 15799-79-8)
- Neostigmine EP Impurity C (CAS 16088-19-0)
- Neostigmine Methyl Sulfate - Impurity A (Bromide Salt) (CAS 1620-19-5)
- Neostigmine Impurity 50 (CAS 16460-28-9)
- Neostigmine Impurity 4 (CAS 19962-04-0)
- Neostigmine impurity 31 (CAS 22237-93-0（free base）)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com