Beclomethasone CAS 4419-39-0
| CAS No. | 4419-39-0 |
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 408.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Beclomethasone is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Beclomethasone (CAS 4419-39-0), molecular formula C22H29ClO5 and molecular weight 408.92 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Beclomethasone (C22H29ClO5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Beclomethasone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 408.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Beclomethasone Standards
- Beclomethasone (CAS CATO-C4X-147422)
- Beclomethasone-d5 (CAS 1263143-48-1)
- Beclomethasone dipropionate Impurity 40 (CAS CATO-C4X-147440)
- Beclomethasone dipropionate Impurity 23 (CAS CATO-C4X-147423)
- Beclomethasone dipropionate Impurity 41 (CAS CATO-C4X-147441)
- Beclomethasone-Δ17,20 21-Aldehyde(E/Z Mixture) (CAS 1174035-77-8&1174035-80-3)
- Beclomethasone dipropionate Impurity 29 (CAS CATO-C4X-147429)
- Beclomethasone dipropionate Impurity 31 (CAS CATO-C4X-147431)
Recommended Standards
- Mometasone Furoate EP Impurity K (CAS 4647-20-5)
- 2,2'-(5-Bromo-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 1150561-62-8)
- Beclometasone Impurity 47 (CAS CATO-C4X-147447)
- 4-Chloro-N-(1-(4-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-2-phenylethyl)benzenesulfonamide (CAS 338954-08-8)
- 4,4'-Methylenebis(2-(trifluoromethyl)aniline) (CAS 15403-97-1)
- 5-Iodo-2-methyl-1H-benzo[d]imidazole (CAS 2818-70-4)
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- potassium ethyl carbonotrithioate (CAS 35444-20-3)
- (3,4-Dichlorophenyl)(4-iodophenyl)methanone (CAS 951891-50-2)
- Chloromethyl cyclopropanecarboxylate (CAS 100108-45-0)
- cis-3-Boc-3,7-diazabicyclo[4.2.0]octane (CAS 1250993-51-1)
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- Cholecystokinin Octapeptide (sulfated) (H-2060.0005) (CAS 25679-23-6)
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