Atorvastatin Impurity 112 CAS 459-57-4
| CAS No. | 459-57-4 |
| Molecular Formula | C7H5FO |
| Molecular Weight | 124.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Atorvastatin Impurity 112 (CAS 459-57-4, C7H5FO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atorvastatin Impurity 112 (C7H5FO) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Atorvastatin Impurity 112 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5FO |
| Molecular Weight | 124.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Atorvastatin Standards
- Atorvastatin Impurity 61 (CAS 405-99-2)
- Atorvastatin Impurity 52 (CAS 42558-54-3)
- Atorvastatin Impurity 54 (CAS 141942-85-0)
- Atorvastatin Impurity 60 (CAS 124401-38-3)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Atorvastatin Impurity N2 (CAS 40281-50-3)
- Atorvastatin Impurity N3 (CAS 77294-82-7)
- Atorvastatin impurity 161 (CAS CATO-C4X-1132161)
Recommended Standards
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- (E)-N'-[(2-Fluorophenyl)methoxy]-N-{thieno[2,3-d]pyrimidin-4-yl}methanimidamide (CAS 477846-33-6)
- 5-(2-(Dimethylamino)ethoxy)-2-fluorobenzonitrile (CAS 1864062-45-2)
- Diethyl (2,4-dichlorobenzyl)phosphonate (CAS 57277-24-4)
- 5-Bromo-2-ethoxypyridine-3-boronic acid pinacol ester (CAS 2121514-85-8)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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